Surgical site infections are hospital-acquired infections resulting in severe risk for patients and significantly increased costs for healthcare providers. In this work, we show how to leverage irregularly sampled preoperative blood tests to predict, on the day of surgery, a future surgical site infection and its severity. Our dataset is extracted from the electronic health records of patients who ...

The density ridge framework for estimating principal curves and surfaces has in a number of recent works been shown to capture manifold structure in data in an intuitive and effective manner. However, to date there exists no efficient way to traverse these manifolds as defined by density ridges. This is unfortunate, as manifold traversal is an important problem for example for shape estimation in ...

Patients with type 1 diabetes must continually decide how much insulin to inject before each meal to maintain blood glucose levels within a healthy range. Recent research has worked on a solution for this burden, showing the potential of reinforcement learning as an emerging approach for the task of controlling blood glucose levels. In this paper, we test and evaluate several deep Q-learning algorithms ...

A wide range of machine learning methods have taken advantage of density estimates and their derivatives, including methodology related to principal manifolds and mode seeking, finding use in a number of real applications. However, research concerned with improving density derivative estimation and its practical use have received relatively limited attention. Also, the fact that the derivatives ...

In this thesis we present a new semi-supervised classification technique based on the Kernel Entropy Component Analysis (KECA) transformation and the least absolute shrinkage selection operator (LASSO). The latter is a constrained version of the least squares classifier. Traditional supervised classification techniques only use a limited set of labeled data to train the classifier, thus leaving ...